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HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a widely used research and clinical formula estimating insulin resistance from a single fasting blood draw: HOMA-IR = (fasting glucose x fasting insulin) / 405 (mg/dL convention) or / 22.5 (mmol/L convention). This calculator is for general reference and educational purposes only — it is not a medical diagnosis. Consult a doctor for actual insulin resistance assessment.
How it works
Select your glucose unit (mg/dL or mmol/L), then enter fasting glucose and fasting insulin. The tool applies the corresponding divisor (405 for mg/dL, 22.5 for mmol/L) automatically.
- Enter glucose unit.
- Enter fasting glucose.
- Enter fasting insulin (µU/mL).
- Click Calculate to see your results.
Examples
Fasting glucose 90 mg/dL, fasting insulin 5 uU/mL
HOMA-IR = (90 x 5) / 405 = 1.11.
Who should use it
- Research and clinical estimation of insulin resistance from routine labs.
- Tracking a fasting insulin-resistance marker over time alongside a doctor.
Industry applications
- Endocrinology and metabolic research
- Primary care metabolic screening
Advantages
- Requires only a single fasting blood draw, unlike more involved clamp-based insulin sensitivity tests.
- Widely used and cited across decades of research literature.
Limitations
- Less precise than the hyperinsulinemic-euglycemic clamp, the research gold standard.
- Reference ranges vary by lab, assay, and population.
Common mistakes to avoid
- Mixing up the mg/dL and mmol/L divisors, which produces a HOMA-IR value off by roughly 18x.
- Using a non-fasting glucose or insulin value, which invalidates the HOMA-IR estimate.
Best practices
- Only use fasting (typically 8-12 hour fast) glucose and insulin values for this calculation.
Tips
- Track HOMA-IR trends over time using consistent fasting conditions and the same lab where possible.